The future of healthcareLearn More

Convenient trumps promising

3099081998_bc5c57dd86_zThe innovator dreams of conditions that are common and for which there are untested treatments. There are many conditions that present in primary care that might fit the bill. Conditions that improve in time regardless of what is done for them. Here are a few examples from a very long list:

  • Common Cold
  • Plantar Warts
  • Molluscum contagiosum
  • Ankle Sprain

Yet there are a number of apparently effective treatments for some of these that have been known for decades. However few have been tested formally in randomised clinical trials. Our team recently attempted to test a traditional remedy in an RCT. Without that evidence the treatment cannot be recommended, even though the ‘gold standard’ can hardly be said to be effective. Ethics committees require patients who are offered participation in a trial to give informed consent. That’s as it should be. There are documents to read, special appointments to make, then follow up for a number of weeks to determine if the treatment is working and then yet more form filling to assess the impact of the treatment. Our team is good at this sort of thing. We design documents that are easy to read and procedures that are simple to follow.

So Jean turns up with 12 year old Megan after school  because has been told by the teacher that Megan can’t go swimming until she has had her warts treated, or Megan has been complaining that the warts are bothering her. Mum knows, or has heard from the woman next door that the doctor can ‘burn’ them off. Not that in many cases the treatment has to be repeated and that mostly it doesn’t work.  And then she is told- ‘ Well there is this trial we are doing…….. blah, blah.’

Never mind that just burn them off doc.

Cryotherapy stings as Megan will discover. The trial treatment is virtually cost free and painless and if it doesn’t work then you still have the cryo option. However mum has been persuaded that cryo works and isn’t interested in anything else- especially something that involves form filling. The woman next door says it worked for her little Freddie. Doctor may not have time to debate the case for testing an alternative in a busy clinic- so the idea is jettisoned and Megan is ushered into the treatment room for cryotherapy.

Here lies a major challenge in testing treatments for which an immediate commercial return is not on the cards. Pharmaceutical companies may not want to put effort into testing something that is unlikely to generate profits and what’s worse is that practitioners may not be willing to invest time promoting research that the patient deems inconvenient. It cannot be assumed that the beneficiary of innovation will participate in a trial if the established treatment is moderately effective and at that point in time convenient.

Picture by Mirko Fontemaggi

Comments

  1. I share your frustration, having been interested in publicising my methods for diagnosing and treating mechanical spinal joint derangements, for a number of years. My website only reaches the general public, so is not the place to teach treatment. I wouldn’t even consider a randomized trial of +/- treatment, as most people walk out feeling better immediately, and have come to expect this. What sort of % improvement would one need to see, to adequately rule out placebo effect? What details about the person and their specific complaint(s) would be needed to allow matching for comparison with a series from another GP not using manual therapy?

  2. Cheers James,
    It is said that 40% of people respond to placebos. Therefore the effect size would need to be very significant to show a difference with relatively modest numbers. Probably the sample size needed to prove the case conclusively would preclude doing your study. Besides the treatment you describe is a complex intervention and would need a specific design (other than an RCT).

    It is disappointing that the conditions we are discussing here are difficult to research in real world conditions. Which means that complimentary and alternative treatments are going to be very hard to get through the conventional scientific routes.

Speak Your Mind

*